VDR is a gene which encodes a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene (rs2228570, FokI polymorphism) is associated with lower bone mineral density in prepubescent girls of white background.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern as well as the temporal on-and-off occupancy of the VDRE between the two components. It is also controlled by chromosomal locations and binding preferences for specific hormones. Microarray studies of human cells show that more than 100 genes carry a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository for data and documents related to legal, business transactions or other proceedings that have restrictions on viewing and downloading. It makes use of a central server as well as an extranet connection which is an Internet connection with restricted access, to provide controlled log-on for set times at which users can browse the documents and data.

Companies and investment banks that are involved in mergers and acquisitions are the most frequent users of VDRs. VDR. They require to communicate information in a clear manner with potential investors or buyers. Due geschaeftsmarketingstrategie diligence procedures can also require a substantial amount of data. Life science companies also use VDRs for everything from clinical trial results to HIPAA compliance documentation.